Disease or Syndrome
gigantism
gi·gan·tism [ jahy-gan-tiz-uhm, ji-, jahy-gan-tiz-uhm ]
Subclass of:
Bone Diseases, Developmental;
Bone Diseases, Endocrine;
Hyperpituitarism
Definitions related to gigantism:
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A clinical finding indicating abnormal and excessive body growth and height resulting from the overproduction of human growth hormone.NCI ThesaurusU.S. National Cancer Institute, 2021
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A condition in which the whole body or any of its parts grow much larger than normal.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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Condition of abnormal overgrowth or excessive size of the whole body or any of its parts.CRISP ThesaurusNational Institutes of Health, 2006
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The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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(pituitary gigantism) A rare endocrine disease characterized by excessively tall stature and rapid growth velocity due to growth hormone excess from a pituitary adenoma/hyperplasia occurring before closure of the epiphyseal growth plates. Additional features may include pubertal delay, visual defects, headache, excessive appetite, hyperhidrosis, menstrual irregularity, prognathism, coarse facial features and large hands/feet.OrphaNetINSERM, 2021
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(pituitary gigantism) Extreme tall stature and other overgrowth manifestations due to increased growth hormone secretion while the skeletal growth plates are open.NICHD Pediatric TerminologyU.S. National Cancer Institute, 2021
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Gigantism is abnormally large growth due to an excess of growth hormone (GH) during childhood, before the bone growth plates have closed (epiphyseal fusion). It causes excessive growth in height, muscles, and organs, making the child extremely large for his or her age. Other symptoms may include delayed puberty; double vision or...National Center for Advancing Translational Sciences
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Gigantism, excessive growth in stature, well beyond the average for the individual's heredity and environmental conditions. Tall stature may result from hereditary, dietary, or other factors. Gigantism is caused by disease or disorder in those parts of the endocrine system that regulate growth and...Encyclopedia Britannica, Inc., 2020
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