Neoplastic Process
glioblastoma
gli·o·blas·to·ma [ glee-oh-blas-toh-muh ]
Subclass of:
Astrocytoma
Etymology:
Greek glia = glue + blastos = germ + -oma = tumor or neoplasm
Definitions related to glioblastoma:
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A fast-growing type of central nervous system tumor that forms from glial (supportive) tissue of the brain and spinal cord and has cells that look very different from normal cells. GBM usually occurs in adults and affects the brain more often than the spinal cord.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Glioblastomas are malignant astrocytic tumors (grade IV according to the WHO classification).OrphaNetINSERM, 2021
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The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)NCI ThesaurusU.S. National Cancer Institute, 2021
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(glioblastoma, not otherwise specified) Glioblastoma in which there is insufficient information on the IDH genes status.NCI ThesaurusU.S. National Cancer Institute, 2021
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Glioblastoma is an aggressive type of cancer that can occur in the brain or spinal cord. Glioblastoma forms from cells called astrocytes that support nerve cells.Mayo Foundation for Medical Education and Research
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Glioblastoma is a malignant (cancerous) brain tumor that develops from a specific type of brain cell called an astrocyte. These cells help support and nourish neurons (nerve cells of the brain) and form scar tissue that helps repair brain damage in response to injury. Glioblastomas are often very aggressive and grow into surrounding...National Center for Advancing Translational Sciences
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