Biologically Active Substance
glutathione
glu·ta·thi·one [ gloo-tuh-thahy-ohn ]
More Information:
Definitions related to glutathione:
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A substance found in plant and animal tissues that has many functions in a cell. These include activating certain enzymes and destroying toxic compounds and chemicals that contain oxygen.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A tripeptide comprised of three amino acids (cysteine, glutamic acid, and glycine) present in most mammalian tissue. Glutathione acts as an antioxidant, a free radical scavenger and a detoxifying agent. Glutathione is also important as a cofactor for the enzyme glutathione peroxidase, in the uptake of amino acids, and in the synthesis of leukotrienes. As a substrate for glutathione S-transferase, this agent reacts with a number of harmful chemical species, such as halides, epoxides and free radicals, to form harmless inactive products. In erythrocytes, these reactions prevent oxidative damage through the reduction of methemoglobin and peroxides. Glutathione is also involved in the formation and maintenance of disulfide bonds in proteins and in the transport of amino acids across cell membranes.NCI ThesaurusU.S. National Cancer Institute, 2021
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A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Tripeptide composed of gamma-glutamate, cysteine, and glycine; an important endogenous reducing agent involved in oxidative respiration and free radical scavenging.CRISP ThesaurusNational Institutes of Health, 2006
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