Pharmacologic Substance
glycopyrrolate
Effect:
Decreased Parasympathetic Acetylcholine Activity; Decreased Respiratory Secretions; Salivation Inhibition
May Treat:
Abnormalities, Drug-Induced; Peptic Ulcer; Respiratory Tract Diseases
More Information:
ChemID; DailyMed; PDR
Definitions related to glycopyrrolate:
  • A muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A synthetic quaternary ammonium that is an anticholinergic agent with antispasmodic activity. Glycopyrrolate competitively binds to peripheral muscarinic receptors in the autonomic effector cells of, and inhibits cholinergic transmission in smooth muscle, cardiac muscle, the sinoatrial (SA) node, the atrioventricular (AV) node, exocrine glands and in the autonomic ganglia. Blockage of cholinergic transmission, in smooth muscle cells located in the gastrointestinal tract and the bladder, causes smooth muscle relaxation and prevents the occurrence of painful spasms. In addition, glycopyrrolate inhibits the release of gastric, pharyngeal, tracheal, and bronchial secretions.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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