Congenital Abnormality
gonadal dysgenesis Audio
[ goh-nad-al, gon-ad-al dis-jen-uh-sis ]
Subclass of:
Disorders of Sex Development
Definitions related to gonadal dysgenesis:
  • A congenital disorder characterized by the presence of extremely hypoplastic gonads preventing the development of secondary sex characteristics.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A number of syndromes with defective gonadal developments such as streak GONADS and dysgenetic testes or ovaries. The spectrum of gonadal and sexual abnormalities is reflected in their varied sex chromosome (SEX CHROMOSOMES) constitution as shown by the karyotypes of 45,X monosomy (TURNER SYNDROME); 46,XX (GONADAL DYSGENESIS, 46XX); 46,XY (GONADAL DYSGENESIS, 46,XY); and sex chromosome MOSAICISM; (GONADAL DYSGENESIS, MIXED). Their phenotypes range from female, through ambiguous, to male. This concept includes gonadal agenesis.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • Abnormal development of a gonad (ovary or testicle). Men with gonadal dysgenesis have a greater risk of developing testicular cancer. Gonadal dysgenesis is usually part of a genetic syndrome.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • Anomalous development of the gonads, resulting in reduced hormone production and germ cell numbers. The gonads are completely or partially underdeveloped and comprise mainly fibrous tissue.
    NICHD Pediatric Terminology
    U.S. National Cancer Institute, 2021
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