Enzyme
helicase
[ hel-i-keys, hee-li ]
Definitions related to dna helicases:
  • (helicase) Helicases are a class of enzymes that utilize the energy of ATP hydrolysis to promote unwinding of 1.) RNA during transcription, splicing and translation or 2.) duplex DNA during replication or repair by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening.
    NCI
    U.S. National Cancer Institute, 2021
  • (helicase) NonEC; ATP-driven topoisomerase which unwinds duplex DNA immediately prior to replication or transcription.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • A class of enzymes that utilizes the energy of ATP hydrolysis to unwind (unzipped) dsDNA. The enzyme participate in various of biological process including DNA replication, transcription and recombination.
    NCI
    U.S. National Cancer Institute, 2021
  • Proteins that catalyze the unwinding of duplex DNA during replication by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. In addition, DNA helicases are DNA-dependent ATPases that harness the free energy of ATP hydrolysis to translocate DNA strands.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
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