Enzyme
hyaluronoglucosaminidase
Brand Names:
Amphadase; Darzalex Faspro; Herceptin Hylecta; Hylenex; Phesgo; Rituxan Hycela; Vitrase
Effect:
Cellular Structure Alteration
May Prevent:
Extravasation of Diagnostic and Therapeutic Materials
May Treat:
Extravasation of Diagnostic and Therapeutic Materials
Definitions related to hyaluronidase:
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An injectable enzyme with potential adjuvant activity. Upon subcutaneous administration, hyaluronidase modifies the permeability of connective tissue by hydrolyzing hyaluronic acid. This temporarily decreases interstitial viscosity and allows drugs that are co-injected to spread rapidly through the interstitial space, thereby facilitating absorption and/or distribution of the co-injected agents.NCI ThesaurusU.S. National Cancer Institute, 2021
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Enzyme preparations are products that are used in the histopathology laboratory for the following purposes: (1) To disaggregate tissues and cells already in established cultures for preparation into subsequent cultures (e.g., trypsin); (2) To disaggregate fluid specimens for cytological examination (e.g., papain for gastric lavage or trypsin for sputum liquefaction); (3) To aid in the selective staining of tissue specimens (e.g., diastase for glycogen determination).Standard Product NomenclatureU.S Food & Drug Administration, 2003
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(hyaluronoglucosaminidase) An enzyme that catalyzes the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. (From Enzyme Nomenclature, 1992) There has been use as ANTINEOPLASTIC AGENTS to limit NEOPLASM METASTASIS.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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