• A tumor of hybrid cells used in the in vitro production of specific monoclonal antibodies; produced by fusion of an established tissue culture line of lymphocyte tumor cells (e.g., mouse plasmacytoma cells) and specific antibody-producing cells (e.g., splenocytes from specifically immunized mice); fusions are accomplished by use of polyethylene glycol or other methods.
  NCI
  U.S. National Cancer Institute, 2021
• Cells artificially created by fusion of activated lymphocytes with neoplastic cells; the resulting hybrid cells are cloned and produce pure or monoclonal antibodies or T-cell products, identical to those produced by the immunologically competent parent, and continually grow and divide as the neoplastic parent.
  CRISP Thesaurus
  National Institutes of Health, 2006