Disease or Syndrome
hyperkeratosis Audio
hy·per·ker·a·to·sis [ hahy-per-ker-uh-toh-sis ]
Etymology:
Greek hyper = excessive + keras = horn + -osis = condition
Definitions related to hyperkeratosis:
  • A condition marked by thickening of the outer layer of the skin, which is made of keratin (a tough, protective protein). It can result from normal use (corns, calluses), chronic inflammation (eczema), or genetic disorders (X-linked ichthyosis, ichthyosis vulgaris).
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • Hyperkeratosis is thickening of the epidermis involving the outer layer of the skin, the stratum corneum, which is composed of large, polyhedral, plate-like envelopes filled with keratin which are the dead cells that have migrated up from the stratum granulosum.
    Human Phenotype Ontology (HPO)
    The Human Phenotype Ontology Project, 2025
  • Hypertrophy of the outermost layer of the epidermis. It may be caused by physical or chemical irritants, irradiation, infection, or neoplastic processes.
    NCI
    U.S. National Cancer Institute, 2021
  • Thickening of the outermost layer of stratified squamous epithelium.
    CDISC Terminology
    Clinical Data Interchange Standards Consortium (CDISC), 2021
  • A disorder characterized by a thickening of the outer layer of the skin.
    Common Terminology Criteria for Adverse Events
    U.S. National Institutes of Health, 2021
Try this search on: Farlex, Merriam-Webster, Oxford Dictionary, or Wordnik

This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.