Pharmacologic Substance
incyclinide
Definitions related to incyclinide:
  • A chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A substance being studied in the treatment of cancer. COL-3 may block the growth of new blood vessels that tumors need to grow. It is a type of matrix metalloproteinase inhibitor and a type of antiangiogenesis agent.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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