Pharmacologic Substance
indapamide
Effect:
Decreased Blood Pressure; Decreased Intravascular Volume; Increased Distal Tubule H+ Excretion; Increased Distal Tubule K+ Excretion; Increased Distal Tubule Na+ Excretion; Increased Diuresis
May Treat:
Edema; Heart Failure; Hypertension; Nephrotic Syndrome
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to indapamide:
  • A benzamide-sulfonamide-indole derived DIURETIC that functions by inhibiting SODIUM CHLORIDE SYMPORTERS.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • An indole derivative of chlorosulphonamide and a sulfamyl diuretic with antihypertensive activity. Indapamide may interact directly with the subunits of delayed rectifier potassium channels, thereby blocking both slow and rapid K+ (IKs and IKr) currents through the channels. Through the homeostasis mechanism in balancing total ion concentration (Ca++, Na+), it reduces vascular hyperreactivity and peripheral and arterial vascular resistance, possibly by inhibiting transmembrane ionic influx, probably calcium ions, and stimulating prostaglandin E2 synthesis, thereby causing vasodilatation. Indapamide exerts its diuretic effect by inhibiting reabsorption of sodium and chloride, primarily as a result of action on the cortical diluting segment of the renal distal tubule, thereby promoting urinary excretion of water and electrolytes.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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