Pharmacologic Substance
indole-3-carbinol Audio
[ in-dole ... kar-bih-nol ]
Definitions related to indole-3-carbinol:
  • A naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, a natural compound present in a wide variety of plant food substances including members of the family Cruciferae with antioxidant and potential chemopreventive properties. Indole-3-carbinol scavenges free radicals and induces various hepatic cytochrome P450 monooxygenases. Specifically, this agent induces the hepatic monooxygenase cytochrome P4501A1 (CYP1A1), resulting in increased 2-hydroxylation of estrogens and increased production of the chemoprotective estrogen 2-hydroxyestrone.
    NCI
    U.S. National Cancer Institute, 2021
  • A substance that is being studied as a cancer prevention drug. It is found in cruciferous vegetables.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An indole with a carbinol group (-C2OH) attached at the 3 position of the pyrrole ring. The chemical structure is C1=CC=C2C(=C1)C(=CN2)CO.
    CRCH Nutrition Terminology
    Cancer Research Center of Hawaii, University of Hawaii, 2021
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