Neoplastic Process
infantile fibrosarcoma
Definitions related to infantile fibrosarcoma:
  • A fibrosarcoma that occurs in infants. It shares identical morphologic features with adult fibrosarcoma but carries the t(12;15)(p13;q25) translocation that results in ETV6-NTRK3 gene fusion. It usually affects the superficial and deep soft tissues of the extremities. The prognosis is generally much more favorable than for adult fibrosarcoma, and it rarely metastasizes.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A fibrosarcoma typically congenital, and occurring most commonly within the first three months of life, sharing identical morphologic features with adult fibrosarcoma but rarely metastatic. It usually affects the superficial and deep soft tissues of the extremities. The majority of infantile fibrosarcomas carry the t(12;15)(p13;q25) translocation.
    NICHD Pediatric Terminology
    U.S. National Cancer Institute, 2021
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