Pharmacologic Substance
irinotecan hydrochloride Audio
[ i-rih-noh-tee-kan hy-droh-klor-ide ]
Effect:
Cellular Proliferation Alteration; Decreased DNA Integrity; Increased Cellular Death
May Treat:
Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Leukemia; Lymphoma; Neoplasm Metastasis; Pancreatic Neoplasms; Rectal Neoplasms; Stomach Neoplasms
More Information:
ChemID; DailyMed; DrugInfo; PDR
Definitions related to irinotecan hydrochloride:
  • A drug used alone or with other drugs to treat colon cancer or rectal cancer that has spread to other parts of the body or has come back after treatment with fluorouracil. It is also being studied in the treatment of other types of cancer. Camptosar blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of topoisomerase inhibitor and a type of camptothecin analog.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • The hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.