Pharmacologic Substance
ixabepilone Audio
[ ik-suh-beh-pih-lone ]
Brand Names:
IXEMPRA
Effect:
Decreased Mitosis; Increased Cellular Death; Microtubule Inhibition
May Treat:
Breast Neoplasms
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to ixabepilone:
  • A drug used to treat metastatic or locally advanced breast cancer that has not improved after treatment with certain other anticancer drugs. It is also being studied in the treatment of other types of cancer. Ixempra stops the growth of tumor cells by blocking cell division. It is a type of epothilone analog.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An orally bioavailable semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.