Disease or Syndrome
job syndrome
job syn·drome
Subclass of:
Primary immune deficiency disorder; Phagocyte Bactericidal Dysfunction
Also called:
Hyper-IgE Syndrome; Buckley Syndrome; Hyperimmunoglobulinemia E Syndrome
Definitions related to job syndrome:
  • Primary immunodeficiency syndrome characterized by recurrent infections and hyperimmunoglobulinemia E. Most cases are sporadic. Of the rare familial forms, the dominantly inherited subtype has additional connective tissue, dental and skeletal involvement that the recessive type does not share.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • (hyperimmunoglobulin e syndrome) A condition that is characterized by elevated serum IgE, dermatitis, and respiratory infections.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Hyper-IgE syndrome is a hereditary combined B- and T-cell immunodeficiency characterized by recurrent staphylococcal abscesses of the skin, sinopulmonary infections, and severe pruritic eosinophilic dermatitis. Diagnosis is confirmed by measurement of serum IgE levels. Treatment consists of supportive measures, including lifelong...
    Merck Manuals
    Merck & Co., Inc., 2020
  • Autosomal dominant hyperimmunoglobulin E (IgE) syndrome (HIES) was first described as Job syndrome in 1966 and included the triad of eosinophilia, eczema, and recurrent skin and pulmonary infections (named after the biblical character Job, who was
    Medscape
    WebMD, 2019
  • Hyper IgE syndromes (HIES) are rare primary immune deficiencies characterized by elevated serum IgE, skin inflammation (dermatitis) and recurrent skin and lung infections. There are two forms of HIES, which have the above characteristics in common but otherwise have distinct presentations, courses and outcomes: autosomal dominant HIES...
    NIH Genetic and Rare Diseases
    National Center for Advancing Translational Sciences
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