Disease or Syndrome
Kartagener syndrome
Subclass of:
Congenital abnormality of respiratory system; Ciliary Motility Disorders; Genetic Diseases, Inborn; Bronchiectasis; Dextrocardia
Definitions related to kartagener syndrome:
  • A rare autosomal recessive inherited syndrome characterized by situs inversus, bronchiectasis, and chronic sinusitis. There is a defect in the function of the cilia that line the respiratory tract.
    NCI
    U.S. National Cancer Institute, 2021
  • An autosomal recessive disorder characterized by a triad of DEXTROCARDIA; INFERTILITY; and SINUSITIS. The syndrome is caused by mutations of DYNEIN genes encoding motility proteins which are components of sperm tails, and CILIA in the respiratory and the reproductive tracts.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • Siewert first described the combination of situs inversus, chronic sinusitis, and bronchiectasis in 1904. However, Manes Kartagener first recognized this clinical triad as a distinct congenital syndrome in 1933.
    Medscape
    WebMD, 2025
  • Immotile cilia syndrome (ICS) is an autosomal recessive disease with extensive genetic heterogeneity characterized by abnormal ciliary motion and impaired mucociliary clearance. Ultrastructural and functional defects of cilia result in the lack of effective ciliary motility, causing abnormal mucociliary clearance.
    Medscape
    WebMD, 2025
  • Kartagener syndrome is a type of p rimary ciliary dyskinesia that is also characterized by situs inversus totalis (mirror-image reversal of internal organs). The signs and symptoms vary but may include neonatal respiratory distress; frequent lung, sinus and middle ear infections beginning in early childhood; and infertility. It can be...
    NIH Genetic and Rare Diseases
    National Center for Advancing Translational Sciences
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