Pharmacologic Substance
ketamine
ke·ta·mine [ kee-tuh-meen, -min ]
Brand Names:
Ketalar; Ketaset; Ketathesia; Ketaved; Vetaket; Zetamine
Effect:
Blood Pressure Alteration; Decreased Cerebral Cortex Organized Electrical Activity; Decreased Midbrain Organized Electrical Activity; Decreased Sensory-Somatic Nervous System Organized Electrical Activity; General Anesthesia; Increased Epinephrine Activity; Increased Norepinephrine Activity
May Prevent:
Pain
May Treat:
Burns;
Pain
More Information:
Definitions related to ketamine:
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A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A cyclohexanone derivative with analgesic and anesthetic properties. Although its mechanism of action is not well understood, ketamine appears exerts complex pharmacological actions including inhibition of biogenic amine uptake, binding to opioid receptors, and inhibition of N-methyl D-aspartate (NMDA) receptors. Because of the involvement of spinal NMDA receptors in the process of central sensitization, this agent may reduce pain perception and induce sedation.NCI ThesaurusU.S. National Cancer Institute, 2021
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A drug used to cause a loss of feeling and awareness and to induce sleep in patients having surgery. It is also being studied in the treatment of nerve pain caused by chemotherapy. Ketamine blocks pathways to the brain that are involved in sensing pain. It is a type of general anesthetic.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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Rapid-acting general anesthetic, animal anesthetic, and emerging drug of abuse.CRISP ThesaurusNational Institutes of Health, 2006
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Ketamine, general anesthetic agent related structurally to the hallucinogen phencyclidine (PCP). Ketamine was first synthesized in 1962 at Parke Davis Laboratories by American scientist Calvin Stevens, who was searching for a new anesthetic to replace PCP, which was not suitable for use in humans...Encyclopedia Britannica, Inc., 2020
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