Pharmacologic Substance
ketamine hydrochloride Audio
ke·ta·mine hy·dro·chlo·ride [ kee-tuh-meen hy-droh-klor-ide ]
Effect:
Blood Pressure Alteration; Decreased Cerebral Cortex Organized Electrical Activity; Decreased Midbrain Organized Electrical Activity; Decreased Sensory-Somatic Nervous System Organized Electrical Activity; General Anesthesia; Increased Epinephrine Activity; Increased Norepinephrine Activity
May Prevent:
Pain
May Treat:
Burns; Pain
More Information:
ChemID; DailyMed; PDR
Definitions related to ketamine hydrochloride:
  • A drug used to cause a loss of feeling and awareness and to induce sleep in patients having surgery. It is also being studied in the treatment of nerve pain caused by chemotherapy. Ketalar blocks pathways to the brain that are involved in sensing pain. It is a type of general anesthetic.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • The hydrochloride salt of a synthetic derivative of cyclohexanone with analgesic and anesthetic activities. Although its mechanism of action is not well understood, ketamine appears to non-competitively block N-methyl-D-aspartate (NMDA) receptors and may interact with opioid mu receptors and sigma receptors, thereby reducing pain perception, inducing sedation, and producing dissociative anesthesia.
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.