Pharmacologic Substance
lacosamide
Brand Names:
Vimpat
May Treat:
Epilepsies, Partial;
Epilepsy, Tonic-Clonic;
Lennox Gastaut Syndrome
More Information:
Definitions related to lacosamide:
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A functionalized amino acid compound specifically synthesized as an anticonvulsive drug to use as add-on therapy for partial-onset seizures with antinociceptive and neuroprotective activities. Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, thereby stabilizing hyperexcitabe neuronal membranes. Furthermore, this agent binds to collapsin response mediator protein 2 (CRMP2; DPYSL2), a cytosolic phosphoprotein expressed in most tissues. In the nervous system, CRMP2 acts as a mediator of growth cone collapse as well as modifies axon number, length, and neuronal polarity.NCI ThesaurusU.S. National Cancer Institute, 2021
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An acetamide derivative that acts as a blocker of VOLTAGE-GATED SODIUM CHANNELS. It is used as an anticonvulsant, for adjunctive or monotherapy, in the treatment of PARTIAL SEIZURES.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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