Pharmacologic Substance
lamotrigine Audio
[ luh-moh-trih-jeen ]
Brand Names:
Lamictal; Subvenite
Effect:
Decreased Central Nervous System Disorganized Electrical Activity; Decreased Glutamate Activity
May Treat:
Bipolar Disorder; Epilepsies, Partial; Lennox Gastaut Syndrome; Seizures
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to lamotrigine:
  • A drug that is used to help control some types of seizures. It is being studied in the prevention of peripheral neuropathy caused by some chemotherapy drugs. It belongs to the family of drugs called anticonvulsants.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A phenyltriazine compound, sodium and calcium channel blocker that is used for the treatment of SEIZURES and BIPOLAR DISORDER.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • A synthetic phenyltriazine with antiepileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake. (NCI04)
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.