Pharmacologic Substance
larotaxel
Definitions related to larotaxel:
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A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier.NCI ThesaurusU.S. National Cancer Institute, 2021
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A substance that is being studied in the treatment of breast cancer. It belongs to the family of drugs called taxane derivatives.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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