Pharmacologic Substance
lestaurtinib
[ leh-stor-tih-nib ]
Definitions related to lestaurtinib:
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A drug being studied in the treatment of acute leukemias and some other types of cancer. It binds to a protein that is present on the surface of some types of cancer cells and stops them from dividing. CEP-701 is a type of receptor tyrosine kinase inhibitor and a type of indolocarbazole alkaloid.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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An orally bioavailable indolocarbazole derivative with antineoplastic properties. Lestaurtinib inhibits autophosphorylation of FMS-like tyrosine kinase 3 (FLT3), resulting in inhibition of FLT3 activity and induction of apoptosis in tumor cells that overexpress FLT3. (NCI05)NCI ThesaurusU.S. National Cancer Institute, 2021
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