Pharmacologic Substance
letrozole
[ leh-truh-zole ]
Brand Names:
Femara
Effect:
Decreased Ovarian Estrogen Secretion
May Treat:
Breast Neoplasms
More Information:
Definitions related to letrozole:
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A drug used to treat advanced breast cancer in postmenopausal women. Letrozole causes a decrease in the amount of estrogen made by the body. It is a type of aromatase inhibitor.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis.NCI ThesaurusU.S. National Cancer Institute, 2021
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A triazole and benzonitrile derivative that is a selective non-steroidal aromatase inhibitor, similar to ANASTROZOLE. It is used in the treatment of metastatic or locally advanced breast cancer in postmenopausal women.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Letrozole, anticancer drug used to inhibit the synthesis of estrogen in postmenopausal women who have breast cancers that are dependent on the growth-promoting actions of the hormone. Letrozole is marketed as Femara and is manufactured by Swiss drug company Novartis AG. Letrozole is taken orally...Encyclopedia Britannica, Inc., 2020
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