Any eicosanoid produced by the oxidation of either eicosapentaenoic acid (EPA) or arachidonic acid (AA) by arachidonate 5-lipoxygenase in leukocytes. Leukotrienes act locally as autocrine or paracrine hormones to modulate immune responses and inflammation.

Family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway; participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation; have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.

A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.

Chemicals that cause airways to swell when an allergic reaction occurs or in diseases like asthma.