Hormone
leuprolide
Brand Names:
Eligard; Fensolvi; Lupron
Effect:
Decreased Follicle Stimulating Hormone Secretion; Decreased GnRH Secretion; Decreased Luteinizing Hormone Secretion; Decreased Ovarian Estrogen Secretion; Decreased Testosterone Secretion
May Treat:
Breast Neoplasms;
Endometrial Neoplasms;
Endometriosis;
Infertility;
Leiomyoma;
Ovarian Neoplasms;
Prostatic Hyperplasia;
Prostatic Neoplasms;
Puberty, Precocious
More Information:
Definitions related to leuprolide:
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A potent synthetic long-acting agonist of GONADOTROPIN-RELEASING HORMONE that regulates the synthesis and release of pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression.NCI ThesaurusU.S. National Cancer Institute, 2021
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GRH/LHRH analog used to suppress circulating gonadotropin and sex steroid levels; USP lists as an antineoplastic.CRISP ThesaurusNational Institutes of Health, 2006
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The active ingredient in a drug used to treat symptoms of advanced prostate cancer. It is also used to treat early puberty in children and certain gynecologic conditions. It is being studied in the treatment of other conditions and types of cancer. Leuprolide blocks the body from making testosterone (a male hormone) and estradiol (a female hormone). It may stop the growth of prostate cancer cells that need testosterone to grow. It is a type of gonadotropin-releasing hormone analog.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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