Pharmacologic Substance
lopinavir
[ loh-pih-nuh-veer ]
Brand Names:
Kaletra
Effect:
Decreased Protein Synthesis; Increased Immunologically Active Molecule Activity
May Treat:
Acquired Immunodeficiency Syndrome
More Information:
Definitions related to lopinavir:
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A drug used with another drug, called ritonavir, to treat infection with HIV (the virus that causes AIDS). It is also being studied in the treatment of some types of cancer. Lopinavir blocks the ability of HIV to make copies of itself and may help some anticancer drugs work better. It is a type of anti-HIV agent and a type of protease inhibitor.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding to serum proteins than the structurally-related drug ritonavir.NCI ThesaurusU.S. National Cancer Institute, 2021
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An HIV protease inhibitor used in a fixed-dose combination with RITONAVIR. It is also an inhibitor of CYTOCHROME P-450 CYP3A.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Very potent inhibitor of HIV-1 protease; often coadministered with RITONAVIR.CRISP ThesaurusNational Institutes of Health, 2006
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