Pharmacologic Substance
losartan
Brand Names:
Cozaar; Hyzaar
Effect:
Decreased Blood Pressure; Decreased Intravascular Volume; Decreased Mineralocorticoid Secretion; Decreased Renal K+ Excretion; Increased Renal Na+ Excretion; Renal Arterial Vasodilation
May Treat:
Diabetic Nephropathies; Heart Failure; Hypertension; Hypertrophy, Left Ventricular; Ventricular Dysfunction, Left
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to losartan:
  • A drug used to treat high blood pressure. Losartan blocks the action of chemicals that make blood vessels constrict (get narrower). It is a type of angiotensin II receptor antagonist.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A non-peptide angiotensin II antagonist with antihypertensive activity. Upon administration, losartan and its active metabolite selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor. This blocks the vasoconstricting and aldosterone-secreting actions of angiotensin II, leading to a decrease in blood pressure. Angiotensin II, formed from angiotensin I by angiotensin-converting enzyme (ACE), stimulates the adrenal cortex to synthesize and secrete aldosterone, which decreases the excretion of sodium and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth muscle.
    NCI
    U.S. National Cancer Institute, 2021
  • An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • Antihypertensive agent; nonpeptide angiotension 1 subtype; angiotension 2 receptor antagonist/inhibitor.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.