Pharmacologic Substance
losartan
Brand Names:
Cozaar; Hyzaar
Effect:
Decreased Blood Pressure; Decreased Intravascular Volume; Decreased Mineralocorticoid Secretion; Decreased Renal K+ Excretion; Increased Renal Na+ Excretion; Renal Arterial Vasodilation
May Treat:
Diabetic Nephropathies;
Heart Failure;
Hypertension;
Hypertrophy, Left Ventricular;
Ventricular Dysfunction, Left
More Information:
Definitions related to losartan:
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A drug used to treat high blood pressure. Losartan blocks the action of chemicals that make blood vessels constrict (get narrower). It is a type of angiotensin II receptor antagonist.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A non-peptide angiotensin II antagonist with antihypertensive activity. Upon administration, losartan and its active metabolite selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor. This blocks the vasoconstricting and aldosterone-secreting actions of angiotensin II, leading to a decrease in blood pressure. Angiotensin II, formed from angiotensin I by angiotensin-converting enzyme (ACE), stimulates the adrenal cortex to synthesize and secrete aldosterone, which decreases the excretion of sodium and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth muscle.NCI ThesaurusU.S. National Cancer Institute, 2021
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An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Antihypertensive agent; nonpeptide angiotension 1 subtype; angiotension 2 receptor antagonist/inhibitor.CRISP ThesaurusNational Institutes of Health, 2006
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