Pharmacologic Substance
losartan potassium
[ loh-sar-tan puh-ta-see-um ]
Effect:
Decreased Blood Pressure; Decreased Intravascular Volume; Decreased Mineralocorticoid Secretion; Decreased Renal K+ Excretion; Increased Renal Na+ Excretion; Renal Arterial Vasodilation
May Treat:
Diabetic Nephropathies;
Heart Failure;
Hypertension;
Hypertrophy, Left Ventricular;
Ventricular Dysfunction, Left
More Information:
Definitions related to losartan potassium:
-
A drug used to treat high blood pressure. Cozaar blocks the action of chemicals that make blood vessels constrict (get narrower). It is a type of angiotensin II receptor antagonist.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
-
The potassium salt of losartan, a non-peptide angiotensin II receptor antagonist with antihypertensive activity. Losartan selectively and competitively binds to the angiotensin II receptor (type AT1) and blocks the binding of angiotensin II to the receptor, thus promoting vasodilatation and counteracting the effects of aldosterone. Converted from angiotensin I by angiotensin-converting enzyme (ACE), angiotensin II stimulates the adrenal cortex to synthesize and secrete aldosterone, decreasing sodium excretion and increasing potassium excretion, and acts as a vasoconstrictor in vascular smooth muscle.NCI ThesaurusU.S. National Cancer Institute, 2021
Return to OpenMD Medical Dictionary
> L
This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.