Pharmacologic Substance
lurtotecan
[ loor-toh-tee-kan ]
Definitions related to lurtotecan:
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A semisynthetic analogue of camptothecin with antineoplastic activity. Lurtotecan selectively stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. As a consequence of the formation of this complex, both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA replication, double strand DNA breakage and triggering of apoptosis. Independent from DNA replication inhibition, lurtotecan also inhibits RNA synthesis, multi-ubiquitination and degradation of topoisomerase I and chromatin reorganization.NCI ThesaurusU.S. National Cancer Institute, 2021
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An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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