Disease or Syndrome
mastocytosis
[ mas-toh-sahy-toh-sis ]
Subclass of:
Mast Cell Activation Disorders; Neoplasms, Connective Tissue
Definitions related to mastocytosis:
  • A clonal myeloproliferative neoplasm characterized by the proliferation and accumulation of neoplastic mast cells in one or multiple organs or organ systems. It is a heterogeneous group of neoplasms, ranging from cutaneous proliferations which may regress spontaneously, to aggressive neoplasms associated with organ failure and short survival.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A rare neoplastic disorder characterized by a clonal proliferation of MAST CELLS, associated with KIT-D816 mutations, and accompanied by aberrant mast cell activation. The abnormal increase of MAST CELLS may occur in only the skin (MASTOCYTOSIS, CUTANEOUS), in extracutaneous tissues involving multiple organs (MASTOCYTOSIS, SYSTEMIC), or in solid tumors (MASTOCYTOMA).
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • Rare disease characterized by an abnormal increase in mast cells in the bone marrow, liver, spleen, lymph nodes, gastrointestinal tract, and skin.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • The presence of an increased number of mast cells and CD34+ mast cell precursors in the body.
    Human Phenotype Ontology (HPO)
    The Human Phenotype Ontology Project, 2021
  • Mastocytosis is mast cell infiltration of skin or other tissues and organs. Symptoms result mainly from mediator release and include pruritus, flushing, and dyspepsia due to gastric hypersecretion. Diagnosis is by skin or bone marrow biopsy or both. Treatment is with antihistamines and control of any underlying disorder.
    Merck Manuals
    Merck & Co., Inc., 2020
  • Mastocytosis is a disorder characterized by mast cell proliferation and accumulation within various organs, most commonly the skin. The World Health Organization (WHO) classification of mastocytosis includes the following: Cutaneous mastocytosis Urticaria pigmentosa Maculopapular cutaneous mastocytosis Diffuse cutaneous mastocytosis...
    Medscape
    WebMD, 2019
  • Mastocytosis occurs when too many mast cells accumulate in the skin and/or internal organs such as the liver, spleen, bone marrow, and small intestines. Mast cells are a type of white blood cell in the immune system. Mast cells are responsible for protecting the body from infection and releasing chemicals to create inflammatory...
    NIH Genetic and Rare Diseases
    National Center for Advancing Translational Sciences
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