• A form of osteosclerosis extending in a linear track mainly through one of the long bones of the upper and lower limbs.
  NLM Medical Subject Headings
  U.S. National Library of Medicine, 2025
• A very rare bone disorder characterized by thickening of the cortex in a linear pattern. Signs and symptoms include joint pain, joint swelling, limb deformity, and changes in the skin covering the bone lesion.
  NCI
  U.S. National Cancer Institute, 2021
• Melorheostosis is a rare skeletal abnormality that causes abnormal growth of new bone tissue on top of existing bones. Signs and symptoms typically appear by late childhood or adolescence. Signs and symptoms may include deformity, contracture, chronic pain, stiffness, and limited range of motion. In some cases, the overlying skin and...
  NIH Genetic and Rare Diseases
  National Center for Advancing Translational Sciences
• Melorheostosis, rare disorder of unknown cause in which cortical bone overgrowth occurs along the main axis of a bone in such a way as to resemble candle drippings. Pain is the major symptom, and stiffness and deformity may result. Usually only one limb and the nearest hip or shoulder are affected....
  Encyclopedia Britannica
  Encyclopedia Britannica, Inc., 2025