Pharmacologic Substance
metformin hydrochloride
[ met-for-min hy-droh-klor-ide ]
Effect:
Decreased Gluconeogenesis; Decreased Glycogenesis; Increased Glucose Transport into Cells
May Treat:
Diabetes Mellitus, Type 2
More Information:
Definitions related to metformin hydrochloride:
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A drug used to treat diabetes mellitus (a condition in which the body cannot control the level of sugar in the blood). It is also being studied in the treatment of cancer. It decreases the amount of glucose (a type of sugar) released into the bloodstream from the liver and increases the body's use of the glucose. Glucophage is a type of antidiabetic agent.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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The hydrochloride salt of the biguanide metformin with antihyperglycemic and potential antineoplastic activities. Metformin inhibits complex I (NADPH:ubiquinone oxidoreductase) of the mitochondrial respiratory chain, thereby increasing the cellular AMP to ATP ratio and leading to activation of AMP-activated protein kinase (AMPK) and regulating AMPK-mediated transcription of target genes. This eventually prevents hepatic gluconeogenesis, enhances insulin sensitivity and fatty acid oxidation and ultimately leads to a decrease in glucose levels. Metformin may exert antineoplastic effects through AMPK-mediated or AMPK-independent inhibition of mammalian target of rapamycin (mTOR), which is up-regulated in many cancer tissues. Furthermore, this agent also inhibits tumor cell migration and invasion by inhibiting matrix metalloproteinase-9 (MMP-9) expression which is mediated through the suppression of transcription activator protein-1 (AP-1) activation.NCI ThesaurusU.S. National Cancer Institute, 2021
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