Pharmacologic Substance
methoxyamine hydrochloride
[ meh-thok-see-uh-meen hy-droh-klor-ide ]
Definitions related to methoxyamine hydrochloride:
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A substance being studied in the treatment of cancer. It blocks the ability of a cell to repair damage to its DNA and may kill cancer cells. It may also help some anticancer drugs work better. It is a type of antineoplastic agent.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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The hydrochloride salt form of methoxyamine, an alkoxyamine with potential chemotherapeutic adjuvant activity. Methoxyamine covalently binds to apurinic/apyrimidinic DNA damage sites and thereby inhibits base excision repair (BER) process, which may prevent repair of DNA strand breaks and result in an induction of apoptosis. This agent may potentiate the anti-tumor activity of alkylating agents.NCI ThesaurusU.S. National Cancer Institute, 2021
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