Pharmacologic Substance
midazolam hydrochloride Audio
[ mih-day-zoh-lam hy-droh-klor-ide ]
Effect:
Increased Central Nervous System GABA Activity
May Treat:
Anxiety Disorders; Psychomotor Agitation; Status Epilepticus
More Information:
ChemID; DailyMed; PDR
Definitions related to midazolam hydrochloride:
  • A drug used to treat anxiety and tension and to relax muscles. It is also being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of benzodiazepine.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • The hydrochloride salt of a short-acting benzodiazepine derivative with an imidazole structure and anxiolytic, amnestic, hypnotic, anticonvulsant and sedative properties. Midazolam binds to the benzodiazepine receptor at the gamma-aminobutyric acid (GABA) receptor-chloride ionophore complex in the central nervous system (CNS), resulting in increases in the opening of chloride channels, membrane hyperpolarization, and the inhibitory effect of GABA. This agent may also interfere with the reuptake of GABA, thereby causing accumulation of GABA in the synaptic cleft.
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.