Antibiotic
mithramycin
[ mith-ruh-my-sin ]
Effect:
Bone Resorption Inhibition; Decreased DNA Integrity; Decreased RNA Integrity
May Treat:
Hypercalcemia;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
Paget Disease, Extramammary;
Testicular Neoplasms
Definitions related to plicamycin:
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A drug used to treat some types of testicular cancer. It is also used to treat a higher-than-normal amounts of calcium in the blood or urine. Plicamycin binds to DNA and prevents cells from making RNA and proteins. It is a type of antineoplastic antibiotic.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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(mithramycin) Tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA; used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors; also used to reduce hypercalcemia, especially that due to malignancies.CRISP ThesaurusNational Institutes of Health, 2006
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