Pharmacologic Substance
mometasone furoate
[ moh-meh-tuh-sone fyoor-oh-ayt ]
Effect:
Decreased Leukotriene Activity; Decreased Prostaglandin Activity; Decreased Protein Synthesis; Decreased Thromboxane Activity; Vasoconstriction
May Treat:
Facial Dermatoses;
Foot Dermatoses;
Hand Dermatoses;
Inflammation;
Leg Dermatoses;
Pruritus;
Rhinitis, Allergic, Perennial;
Scalp Dermatoses
More Information:
Definitions related to mometasone furoate:
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A drug that is used in a cream to treat certain skin conditions and in a nasal spray to treat sinus problems caused by allergies. It is being studied as a way to treat inflammation of the skin caused by radiation therapy. Elocon is a type of corticosteroid.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERGIC RHINITIS. It is also used as a topical treatment for skin disorders.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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The furoate ester form of mometasone, a synthetic topical glucocorticoid receptor (GR) agonist with anti-inflammatory, anti-pruritic and vasoconstrictive properties. Upon administration, mometasone binds to cytoplasmic GRs and subsequently activates GR-mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, mometasone appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from phospholipid membrane by phospholipase A2.NCI ThesaurusU.S. National Cancer Institute, 2021
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