Organism Attribute
multi-drug resistance
Subclass of:
Drug resistance
Definitions related to multi-drug resistance:
  • (multidrug resistance) Adaptation of tumor cells to anticancer drugs in ways that make the drugs less effective.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • (multidrug resistance) Characteristic of certain cancer cells and infectious microorganisms, where resistance develops to a broad variety of chemically unrelated drugs; may be due to genetic induction of a membrane pump (P glycoprotein) or other mechanisms.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • (drug resistance, multiple) Simultaneous resistance to several structurally and functionally distinct drugs.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2025
  • (multidrug resistance process) Simultaneous resistance to a spectrum of unrelated drugs following exposure to a single agent. Mechanisms involve expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, decreased topoisomerase II activity, and changes in various cellular proteins.
    NCI
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.