Pharmacologic Substance
muparfostat
Definitions related to muparfostat:
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A mixture of highly sulfated, monophosphorylated mannose oligosaccharides, derived from the extracellular phosphomannan of the yeast Pichia (Hansenula) holstii, with potential antiangiogenic activity. Muparfostat inhibits the endo-beta-D-glucuronidase heparanase, which may interfere with the heparanase-mediated degradation of heparan-sulfate proteoglycans in extracellular matrices, an important step in the metastatic process. This agent may also bind with high affinity to the heparan sulfate-binding domains of vascular endothelial growth factor (VEGF) and fibroblast growth factors 1 and 2, thereby reducing their functional activities and inhibiting VEGF and FGF stimulation of tumor angiogenesis. Increased heparanase activity has been implicated in tumor angiogenesis and metastasis.NCI ThesaurusU.S. National Cancer Institute, 2021
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A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antiangiogenesis agents.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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