A chronic autoimmune neuromuscular disorder characterized by skeletal muscle weakness. It is caused by the blockage of the acetylcholine receptors at the neuromuscular junction.

A disease in which antibodies made by a person's immune system prevent certain nerve-muscle interactions. It causes weakness in the arms and legs, vision problems, and drooping eyelids or head. It may also cause paralysis and problems with swallowing, talking, climbing stairs, lifting things, and getting up from a sitting position. The muscle weakness gets worse during activity, and improves after periods of rest.

A disorder of neuromuscular transmission characterized by fatigable weakness of cranial and skeletal muscles with elevated titers of ACETYLCHOLINE RECEPTORS or muscle-specific receptor tyrosine kinase (MuSK) autoantibodies. Clinical manifestations may include ocular muscle weakness (fluctuating, asymmetric, external ophthalmoplegia; diplopia; ptosis; and weakness of eye closure) and extraocular fatigable weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles (ocular myasthenia). THYMOMA is commonly associated with this condition.

Disease characterized by progressive weakness and exhaustibility of voluntary muscles without atrophy or sensory disturbance and caused by an autoimmune attack on acetylcholine receptors at the neuromuscular junction.

Myasthenia gravis, sometimes called MG, is a chronic (long-lasting) disease that causes weakness in your voluntary muscles. The voluntary muscles are the ones that you can control. They include the muscles you use for: Eye and eyelid movement; Facial expressions; Chewing; Talking; Swallowing; Breathing; Moving your arms and legs. You can also have weakness in other muscles. This weakness gets worse with activity, and better with rest. Myasthenia gravis is a type of autoimmune disease. In autoimmune diseases, your immune system attacks the healthy cells of your organs and tissues by mistake. Myasthenia gravis is caused by an error in how nerve signals are sent to muscles. These signals get blocked at the nerve-muscle junction. This junction is the place where the nerve endings connect with the muscles they control. Normally, this is how the signals work: The signals travel down a nerve that controls movement in the muscle; The nerve endings release a substance called acetylcholine; Acetylcholine binds to the muscle tissue at the nerve-muscle junction; This causes the muscle to contract (move). But in someone with myasthenia gravis, the body's own immune system makes antibodies that block the binding of acetylcholine to the muscle. This makes the muscles weaker. The thymus gland, which is part of your immune system, may play a role in myasthenia gravis. Normally, your thymus gland is active and growing when you are a child. It makes white blood cells to fight infections. At puberty, it starts getting smaller and is replaced by fat. It is usually small by the time you are an adult. But in many adults with myasthenia gravis, the thymus gland stays large. And some people with myasthenia gravis can get thymomas, which are tumors of the thymus. The are usually benign (not cancer), but they can sometimes become cancerous. Although myasthenia gravis can affect people of any age, it is most common in young adult women (under age 40) and older men (over age 60). It is usually not inherited (passed down in families). Myasthenia gravis normally does not affect infants. But it's possible for pregnant people who have myasthenia gravis to pass the antibodies to their unborn babies. The baby can then be born with neonatal myasthenia. This condition is usually temporary, and the symptoms typically go away within two to three months after birth. The symptoms of myasthenia gravis will depend on which muscles are affected. The symptoms often include: Weakness of the eye muscles; Drooping of one or both eyelids; Blurred or double vision; Changes in facial expressions; Trouble swallowing; Shortness of breath; Speech problems; Weakness in the arms, hands, fingers, legs, and neck. Different people have different levels of muscle weakness. And the weakness can vary from day to day. Some days it might be mild, and other days it might be worse. Physical activity often makes the muscle weakness worse. Some people with myasthenia gravis can get severe weakness that affects the muscles that control breathing. This is called a myasthenic crisis, and it is a life-threatening emergency. There are many other conditions that can cause muscle weakness, so myasthenia gravis can be hard to diagnose. To find out if you have myasthenia gravis, your health care provider: Will ask about your medical history and symptoms; Will do a physical exam, including a neurological exam; Will likely order tests for myasthenia gravis, including: Blood tests; Imaging tests; Electromyography (EMG) and nerve conduction studies. . There is no cure for myasthenia gravis, but treatments that can improve...

Myasthenia gravis, sometimes called MG, is a chronic (long-lasting) disease that causes weakness in your voluntary muscles. The voluntary muscles are the ones that you can control. They include the muscles you use for: Eye and eyelid movement; Facial expressions; Chewing; Talking; Swallowing; Breathing; Moving your arms and legs. You can also have weakness in other muscles. This weakness gets worse with activity, and better with rest. Myasthenia gravis is a type of autoimmune disease. In autoimmune diseases, your immune system attacks the healthy cells of your organs and tissues by mistake. Myasthenia gravis is caused by an error in how nerve signals are sent to muscles. These signals get blocked at the nerve-muscle junction. This junction is the place where the nerve endings connect with the muscles they control. Normally, this is how the signals work: The signals travel down a nerve that controls movement in the muscle; The nerve endings release a substance called acetylcholine; Acetylcholine binds to the muscle tissue at the nerve-muscle junction; This causes the muscle to contract (move). But in someone with myasthenia gravis, the body's own immune system makes antibodies that block the binding of acetylcholine to the muscle. This makes the muscles weaker. The thymus gland, which is part of your immune system, may play a role in myasthenia gravis. Normally, your thymus gland is active and growing when you are a child. It makes white blood cells to fight infections. At puberty, it starts getting smaller and is replaced by fat. It is usually small by the time you are an adult. But in many adults with myasthenia gravis, the thymus gland stays large. And some people with myasthenia gravis can get thymomas, which are tumors of the thymus. The are usually benign (not cancer), but they can sometimes become cancerous. Although myasthenia gravis can affect people of any age, it is most common in young adult women (under age 40) and older men (over age 60). It is usually not inherited (passed down in families). Myasthenia gravis normally does not affect infants. But it's possible for pregnant people who have myasthenia gravis to pass the antibodies to their unborn babies. The baby can then be born with neonatal myasthenia. This condition is usually temporary, and the symptoms typically go away within two to three months after birth. The symptoms of myasthenia gravis will depend on which muscles are affected. The symptoms often include: Weakness of the eye muscles; Drooping of one or both eyelids; Blurred or double vision; Changes in facial expressions; Trouble swallowing; Shortness of breath; Speech problems; Weakness in the arms, hands, fingers, legs, and neck. Different people have different levels of muscle weakness. And the weakness can vary from day to day. Some days it might be mild, and other days it might be worse. Physical activity often makes the muscle weakness worse. Some people with myasthenia gravis can get severe weakness that affects the muscles that control breathing. This is called a myasthenic crisis, and it is a life-threatening emergency. There are many other conditions that can cause muscle weakness, so myasthenia gravis can be hard to diagnose. To find out if you have myasthenia gravis, your health care provider: Will ask about your medical history and symptoms; Will do a physical exam, including a neurological exam; Will likely order tests for myasthenia gravis, including: Blood tests; Imaging tests; Electromyography (EMG) and nerve conduction studies. . There is no cure for myasthenia gravis, but treatments that can improve...

A disorder characterized by weakness and rapid fatigue of any of the skeletal muscles.

Myasthenia gravis involves episodic muscle weakness and easy fatigability caused by autoantibody- and cell-mediated destruction of acetylcholine receptors. It is more common among young women and older men but may occur in men or women at any age. Symptoms worsen with muscle activity and lessen with rest. Diagnosis is by measurement of...

Myasthenia gravis (MG) is a relatively rare autoimmune disorder in which antibodies form against acetylcholine nicotinic postsynaptic receptors at the neuromuscular junction of skeletal muscles (see the image below). MG is sometimes identified as having an ocular and generalized form, although one is not exclusive of the other and the...

Myasthenia gravis (my-us-THEE-nee-uh GRAY-vis) is characterized by weakness and rapid fatigue of any of the muscles under your voluntary control. It's caused by a breakdown in the normal communication between nerves and muscles.

Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disease characterized by weakness of the skeletal muscles. Common symptoms include weakness of the muscles that control the eye and eyelid, facial expressions, chewing, talking, and swallowing. Weakness tends to increase during periods of activity and improve after periods of...

Myasthenia gravis (MG) is a chronic autoimmune disorder of the postsynaptic membrane at the neuromuscular junction (NMJ) in skeletal muscle. Circulating antibodies against the nicotinic acetylcholine receptor (AChR) and associated proteins impair neuromuscular transmission. Patients present with muscle weakness, which typically worsens...

Myasthenia gravis, chronic autoimmune disorder characterized by muscle weakness and chronic fatigue that is caused by a defect in the transmission of nerve impulses from nerve endings to muscles. Myasthenia gravis can occur at any age, but it most commonly affects women under the age of 40 and men...