Pharmacologic Substance
mycophenolate mofetil
[ my-koh-feh-noh-layt moh-feh-til ]
Brand Names:
Cellcept
Effect:
Decreased Immunologically Active Molecule Activity; Decreased Lymphocyte Cell Production
May Prevent:
Graft vs Host Disease
May Treat:
Graft vs Host Disease;
Psoriasis
More Information:
Definitions related to mycophenolate mofetil:
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A drug used to prevent graft-versus-host disease (GVHD) after organ transplants. It is also being studied in the prevention of GVHD after stem cell transplants for cancer, and in the treatment of some autoimmune disorders. Mycophenolate mofetil is a type of immunosuppressive agent.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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Immunosuppressant used in the prophylaxis of organ rejection.CRISP ThesaurusNational Institutes of Health, 2006
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The morpholinoethyl ester of mycophenolic acid (MPA) with potent immunosuppressive properties. Mycophenolate stops T-cell and B-cell proliferation through selective inhibition of the de novo pathway of purine biosynthesis. In vivo, the active metabolite, MPA, reversibly inhibits inosine 5'-monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of guanine nucleotides. MPA displays high lymphocyte specificity and cytotoxicity due to the higher dependence of activated lymphocytes on both salvage and de novo synthesis of guanine nucleotides relative to other cell types. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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