Antibiotic
mycophenolic acid
Brand Names:
Myfortic
Effect:
Decreased Immunologically Active Molecule Activity; Decreased Lymphocyte Cell Production
May Prevent:
Graft vs Host Disease
May Treat:
Graft vs Host Disease;
Psoriasis
More Information:
Definitions related to mycophenolic acid:
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An antineoplastic antibiotic derived from various Penicillium fungal species. Mycophenolic acid is an active metabolite of the prodrug mycophenolate mofetil. Mycophenolic acid inhibits inosine monophosphate dehydrogenase (IMPDH), preventing the formation of guanosine monophosphate and synthesis of lymphocyte DNA that results in inhibition of lymphocyte proliferation, antibody production, cellular adhesion, and migration of T and B lymphocytes. Mycophenolic acid also has antibacterial, antifungal, and antiviral activities. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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Antibiotic substance derived from Penicillium stoloniferum and related species which blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase; mycophenolic acid has selective effects on the immune system, preventing the proliferation of T cells, lymphocytes, and the formation of antibodies from B cells.CRISP ThesaurusNational Institutes of Health, 2006
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Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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