A disorder in which the bone marrow is replaced by fibrous tissue.

A partial or complete replacement of the bone marrow stroma by fibrous tissue. It can be a primary bone marrow lesion as part of the chronic myeloproliferative disorders (chronic idiopathic myelofibrosis), a manifestation of acute myeloid leukemia (acute panmyelosis with myelofibrosis), or a secondary phenomenon due to bone marrow involvement by a metastatic tumor (e.g., metastatic breast carcinoma). --2003

Replacement of bone marrow by fibrous tissue.

Replacement of the bone marrow by fibrous tissue, occurring in association with a myeloproliferative disorder or secondary to another unrelated condition.

(primary myelofibrosis) A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Myelofibrosis is a disorder in which fibrous tissue in the bone marrow replaces the blood-producing cells, resulting in abnormally shaped red blood cells, anemia, and an enlarged spleen.

Myelofibrosis is an uncommon type of bone marrow cancer that disrupts your body's normal production of blood cells.

Myelofibrosis is a reactive process common to many malignant and benign disorders. Primary myelofibrosis (PMF) is a chronic myeloproliferative disorder of unknown etiology. It involves a multipotent hematopoietic progenitor cell, but lacking a specific clonal marker, which results in abnormalities in RBC, WBC, and platelet production in...