Neoplastic Process
myelofibrosis
[ mahy-uh-loh-fahy-broh-sis ]
Definitions related to myelofibrosis:
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A disorder in which the bone marrow is replaced by fibrous tissue.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A partial or complete replacement of the bone marrow stroma by fibrous tissue. It can be a primary bone marrow lesion as part of the chronic myeloproliferative disorders (chronic idiopathic myelofibrosis), a manifestation of acute myeloid leukemia (acute panmyelosis with myelofibrosis), or a secondary phenomenon due to bone marrow involvement by a metastatic tumor (e.g., metastatic breast carcinoma). --2003NCI ThesaurusU.S. National Cancer Institute, 2021
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Replacement of bone marrow by fibrous tissue.Human Phenotype Ontology (HPO)The Human Phenotype Ontology Project, 2021
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Replacement of the bone marrow by fibrous tissue, occurring in association with a myeloproliferative disorder or secondary to another unrelated condition.CRISP ThesaurusNational Institutes of Health, 2006
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(primary myelofibrosis) A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.OrphaNetINSERM, 2021
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Myelofibrosis is a disorder in which fibrous tissue in the bone marrow replaces the blood-producing cells, resulting in abnormally shaped red blood cells, anemia, and an enlarged spleen.Merck & Co., Inc., 2020
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Myelofibrosis is an uncommon type of bone marrow cancer that disrupts your body's normal production of blood cells.Mayo Foundation for Medical Education and Research
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Myelofibrosis is a reactive process common to many malignant and benign disorders. Primary myelofibrosis (PMF) is a chronic myeloproliferative disorder of unknown etiology. It involves a multipotent hematopoietic progenitor cell, but lacking a specific clonal marker, which results in abnormalities in RBC, WBC, and platelet production in...Athenahealth, Inc., 2019
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