Organ or Tissue Function
necrosis
ne·cro·sis [ nuh-kroh-sis, ne- ]
Subclass of:
Pathologic Processes
Etymology:
Greek nekrosis = deadness
Definitions related to necrosis:
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Death of a group of cells in an organ or tissue. (INHAND)CDISC TerminologyClinical Data Interchange Standards Consortium (CDISC), 2021
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Refers to the death of tissues.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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(necrotic) Relating to or affected by necrosis.NCI ThesaurusU.S. National Cancer Institute, 2021
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Sum of the morphological changes indicative of cell death and caused by the progressive degradation action of enzymes; may affect groups of cells or part of a structure or an organ.CRISP ThesaurusNational Institutes of Health, 2006
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The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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The pathologic death of cells or of a portion of tissue or organ resulting from irreversible damage.U.S. FDA GlossaryU.S. Food & Drug Administration, 2021
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The premature death of living cells or tissues.Harvard Dictionary of Health TermsHarvard Medical Publishing, 2011
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(necrotic process) A cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.NCI ThesaurusU.S. National Cancer Institute, 2021
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(necrotic cell death) A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues.Gene Ontology DictionaryGene Ontology Consortium, 2021
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Necrosis, death of a circumscribed area of plant or animal tissue as a result of disease or injury. Necrosis is a form of premature tissue death, as opposed to the spontaneous natural death or wearing out of tissue, which is known as necrobiosis. Necrosis is further distinguished from apoptosis, or...Encyclopedia Britannica, Inc., 2020
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