(neuroblastoma, malignant) A malignant neoplasm composed of neuroblastic cells.

A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

A malignant neoplasm comprised of neuroblasts that commonly arises in or near the adrenal glands.

A malignant neuroblastic tumor characterized by the presence of neuroblastic cells, the absence of ganglion cells, and the absence of a prominent Schwannian stroma formation.

ALK-related neuroblastic tumor susceptibility is characterized by increased risk for neuroblastic tumors including neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. Neuroblastoma is a more malignant tumor and ganglioneuroma a more benign tumor. Depending on the histologic findings, ganglioneuroblastoma can behave in a more aggressive fashion, like neuroblastoma, or in a benign fashion, like ganglioneuroma. Preliminary data from the ten reported families with ALK-related neuroblastic tumor susceptibility suggest an overall penetrance of approximately 57% with the risk for neuroblastic tumor development highest in infancy and decreasing by late childhood.

Cancer that arises in immature nerve cells and affects mostly infants and children.

Common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death; histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa; the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system.

Neuroblastoma is a solid tumor that originate in neural crest cells of the sympathetic nervous system. Most neuroblastomas originate in the abdomen, and most abdominal neuroblastomas originate in the adrenal gland. Neuroblastomas can also originate in the thorax, usually in the posterior mediastinum.

Neuroblastoma is a type of cancer that forms in nerve cells called neuroblasts. Neuroblasts are immature nerve tissue. They normally turn into working nerve cells. But in neuroblastoma, they form a tumor. Neuroblastoma usually begins in the adrenal glands. You have two adrenal glands, one on top of each kidney. The adrenal glands make important hormones that help control heart rate, blood pressure, blood glucose (blood sugar), and the way the body reacts to stress. Neuroblastoma may also begin in the neck, chest or spinal cord. Neuroblastoma is caused by changes in your genes. Gene changes also called gene variants or mutations. In most cases, the cause of the mutation is unknown. In some other cases, the mutation is passed from the parent to the child. Neuroblastoma often begins in early childhood. Sometimes it begins before a child is born.The most common symptoms are caused by the tumor pressing on nearby tissues as it grows or by cancer spreading to the bone.They include: A lump in the abdomen, neck, or chest; Bulging eyes; Dark circles around the eyes; Bone pain; Swollen stomach and trouble breathing in babies; Painless, bluish lumps under the skin in babies; Weakness or paralysis (loss of ability to move a body part). To diagnose neuroblastoma, your child's health care provider will do various tests and procedures, which may include: A medical history.; A neurological exam.; Imaging tests, such as x-rays, a CT scan, an ultrasound, an MRI, or an MIBG scan. In an MIBG scan, a small amount of a radioactive substance is injected into a vein. It travels through the bloodstream and attaches itself to any neuroblastoma cells. A scanner detects the cells.; Blood and urine tests.; Biopsy, in which a sample of tissue is removed and examined under a microscope.; Bone marrow aspiration and biopsy, in which bone marrow, blood, and a small piece of bone are removed for testing. The treatments for neuroblastoma include: Observation, also called watchful waiting, is where the health care provider does not give any treatments until your child's signs or symptoms appear or change.; Surgery; Radiation therapy.; Chemotherapy.; High-dose chemotherapy and radiation therapy with stem cell rescue. Your child will get high doses of chemotherapy and radiation. This kills the cancer cells, but it also kills healthy cells. So your child will get a stem cell transplant, usually of his or her own cells collected earlier. This helps to replace the healthy cells that were lost.; Iodine 131-MIBG therapy, a treatment with radioactive iodine. The radioactive iodine collects in neuroblastoma cells and kills them with the radiation that is given off.; Targeted therapy, which uses drugs or other substances that attack specific cancer cells with less harm to normal cells. NIH: National Cancer Institute

Neuroblastoma is a cancer arising in the adrenal gland or less often from the extra-adrenal sympathetic chain, including in the retroperitoneum, chest, and neck. Diagnosis is confirmed by biopsy. Treatment may include surgical resection, chemotherapy, radiation therapy, high-dose chemotherapy with stem cell transplantation, cis-retinoic...

Neuroblastoma is the most common intra-abdominal malignancy of infancy, the most common cancer in infancy, and the most common extracranial solid tumor of childhood, with an incidence of over 700 cases in the United States every year. Neuroblastoma is the third most common malignancy in children up through 14 years of age, behind acute...

Neuroblastoma is a cancer that develops from immature nerve cells found in several areas of the body.

Neuroblastoma is a tumor that develops from neuroblasts (immature nerve tissue) in an infant or child, usually before the age of 5. It most often develops in infancy and may be diagnosed in the first month of life. The tumor most often develops in the adrenal gland, but may develop in the neck, chest, or spinal cord. It is considered an...

A malignant tumor arising from the embryologic neural crest element of the peripheral sympathetic nervous system. It most commonly arises from the adrenal gland(s), but can form anywhere that sympathetic nervous tissue is present, including paraspinal sympathetic ganglia in the chest and abdomen.

Neuroblastoma, a tumour of the sympathetic nervous system (the branch of the autonomic nervous system that is best known for producing the fight-or-flight response) that affects young children. It is the most-common pediatric solid tumour that occurs outside the brain, with an annual incidence of...