Pharmacologic Substance
nifurtimox
Brand Names:
Lampit
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to nifurtimox:
  • A nitrofuran derivative with antiprotozoal and potential antineoplastic activities. Nifurtimox is reduced by cytosol enzymes or flavin-containing microsomal enzymes to a highly reactive nitro anion free radical; autooxidation of the nitro anion free radical generates cytotoxic superoxide anion (02-). In addition, nifurtimox-derived nitro anion free radicals may alkylate macromolecules such as nucleic acids and proteins, resulting in the disruption of their structure and function.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A nitrofuran thiazine that has been used against TRYPANOSOMIASIS.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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