Pharmacologic Substance
nitrofurantoin
ni·tro·fur·an·to·in [ nahy-troh-fyoo-ran-toh-in ]
Brand Names:
Furadantin; Macrobid; Macrodantin
Effect:
Decreased Cell Wall Synthesis & Repair; Decreased DNA Replication; Decreased Metabolic Rate; Decreased Protein Synthesis
May Prevent:
Urinary Tract Infections
May Treat:
Escherichia coli Infections;
Klebsiella Infections;
Staphylococcal Infections;
Urinary Tract Infections
More Information:
Definitions related to nitrofurantoin:
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A synthetic derivative of imidazolidinedione, Nitrofurantoin inhibits bacterial DNA, RNA, and cell wall protein synthesis. Activated by bacterial flavoproteins to intermediates that inactivate bacterial ribosomal proteins, Nitrofurantoin is used prophylactically as a urinary anti-infective agent against most gram-positive and gram-negative organisms and for long-term suppression of infections. (NCI04)NCI ThesaurusU.S. National Cancer Institute, 2021
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A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Nitrofurantoin is a bactericidal antibiotic; the exact mechanism is unknown. Nitrofurantoin is available only for oral use.Merck & Co., Inc., 2020
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