Pharmacologic Substance
nitrofurantoin Audio
ni·tro·fur·an·to·in [ nahy-troh-fyoo-ran-toh-in ]
Brand Names:
Furadantin; Macrobid; Macrodantin
Effect:
Decreased Cell Wall Synthesis & Repair; Decreased DNA Replication; Decreased Metabolic Rate; Decreased Protein Synthesis
May Prevent:
Urinary Tract Infections
May Treat:
Escherichia coli Infections; Klebsiella Infections; Staphylococcal Infections; Urinary Tract Infections
More Information:
ChemID; DrugBank; DailyMed; PDR
Definitions related to nitrofurantoin:
  • A synthetic derivative of imidazolidinedione, Nitrofurantoin inhibits bacterial DNA, RNA, and cell wall protein synthesis. Activated by bacterial flavoproteins to intermediates that inactivate bacterial ribosomal proteins, Nitrofurantoin is used prophylactically as a urinary anti-infective agent against most gram-positive and gram-negative organisms and for long-term suppression of infections. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • Nitrofurantoin is a bactericidal antibiotic; the exact mechanism is unknown. Nitrofurantoin is available only for oral use.
    Merck Manuals
    Merck & Co., Inc., 2020
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.