Pharmacologic Substance
nimodipine
[ ny-moh-dih-peen ]
Brand Names:
Nimotop; Nymalize
Effect:
Cerebral Arterial Vasodilation; Coronary Arterial Vasodilation
May Treat:
Subarachnoid Hemorrhage
More Information:
Definitions related to nimodipine:
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1,4 dihydropyridine; centrally acting calcium channel blocker used in the treatment of a wide range of disorders, including drug withdrawal, AIDS motor/cognitive disorder, and post cardiac surgery recovery.CRISP ThesaurusNational Institutes of Health, 2006
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A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation. Nimodipine has a greater effect on cerebral arteries than on peripheral smooth muscle cells and myocardial cells, probably because this agent can cross the blood brain barrier due to its lipophilic nature. Furthermore, this agent also inhibits the drug efflux pump P-glycoprotein, which is overexpressed in some multi-drug resistant tumors, and may improve the efficacy of some antineoplastic agents.NCI ThesaurusU.S. National Cancer Institute, 2021
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Belongs to a family of drugs called calcium channel blockers. It is being investigated for use with anticancer drugs to prevent or overcome drug resistance and improve response to chemotherapy.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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