Pharmacologic Substance
omacetaxine mepesuccinate
[ oh-mah-seh-tak-seen meh-peh-suk-sih-nayt ]
Brand Names:
Synribo
More Information:
Definitions related to omacetaxine mepesuccinate:
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(homoharringtonine) An anticancer drug that belongs to the plant alkaloid family of drugs.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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(homoharringtonine) Semisynthetic derivative of harringtonine that acts as a protein synthesis inhibitor and induces APOPTOSIS in tumor cells. It is used in the treatment of MYELOID LEUKEMIA, CHRONIC.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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A semisynthetic formulation of the cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus with potential antineoplastic activity. Omacetaxine mepesuccinate binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. This agent also induces differentiation and apoptosis in some cancer cell types.NCI ThesaurusU.S. National Cancer Institute, 2021
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