Gene or Genome
oncogene
on·co·gene [ ong-kuh-jeen ]
Subclass of:
Genes, Neoplasm
Definitions related to oncogenes:
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A gene that is a mutated (changed) form of a gene involved in normal cell growth. Oncogenes may cause the growth of cancer cells. Mutations in genes that become oncogenes can be inherited or caused by being exposed to substances in the environment that cause cancer.NCI Dictionary of Cancer TermsU.S. National Cancer Institute, 2021
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A gene that normally directs cell growth. If mutated or overexpressed in a dominant fashion, it can release the cell from normal restraints on growth. It alone or in concert with other changes, converts the cell into a tumor cell. Alterations can be inherited or caused by an environmental exposure to carcinogens.NCI ThesaurusU.S. National Cancer Institute, 2021
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A gene that, under certain conditions, can cause cancer.Harvard Dictionary of Health TermsHarvard Medical Publishing, 2011
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Endogenous or acquired genes whose presence or activation leads to neoplastic transformation; compare with TUMOR SUPPRESSOR GENE and PROTOONCOGENE.CRISP ThesaurusNational Institutes of Health, 2006
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Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.NLM Medical Subject HeadingsU.S. National Library of Medicine, 2021
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Oncogene, genetic material that carries the ability to induce cancer. An oncogene is a sequence of deoxyribonucleic acid (DNA) that has been altered or mutated from its original form, the proto-oncogene. Operating as a positive growth regulator, the proto-oncogene is involved in promoting the...Encyclopedia Britannica, Inc., 2020
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